9.Intravital imaging strategy FlyVAB reveals the dependence of Drosophila enteroblastdifferentiation on the local physiology.

Ruizhi Tang, Peizhong Qin, Xiqiu Liu, Song Wu, Ruining Yao, Guangjun Cai, Junjun Gao, You Wu, Zheng Guo

Commun Biol. 2021 Oct 25;4(1):1223.doi: 10.1038/s42003-021-02757-z.  PMID: 34697396 

https://doi.org/10.1038/s42003-021-02757-z

8.Liquid Metal Microscale Deposition enabled High Resolution and Density Epidermal Microheater for Localized Ectopic Expression in Drosophila

Wang Bei, Gao Junjun (co-first author), Jiang Jiajun, Hu Zenghui, Hjort Klas, Guo Zheng, Wu Zhigang

Advanced Materials Technologies doi: 10.1002/admt.202100903

https://doi.org/10.1002/admt.202100903

7.Notch signaling governs the expression of glypican Dally to define the stem cell niche.

Songhua Zhao, Chan Wu, Zhiyang Gao, Xin Li, Zheng Guo, Zhaohui Wang

Biol Open. 2020 Jan 10;9(1):bio047696.doi: 10.1242/bio.047696. PMID: 31826854

https://doi.org/10.1242/bio.047696

6.Peroxisome Elevation Induces Stem Cell Differentiation and Intestinal Epithelial Repair

Gang Du, Lishou Xiong, Xiaorong Li, Zhangpeng Zhuo, Xiaojun Zhuang, Zihua Yu, Lijian Wu, Danqing Xiao, Zhiming Liu, Minwen Jie, Xuehong Liu, Guanzheng Luo, Zheng Guo, Haiyang Chen

Dev Cell. 2020 Apr 20;53(2):169-184.e11.doi: 10.1016/j.devcel.2020.03.002. Epub 2020 Apr 2.  PMID: 32243783

https://doi.org/10.1016/j.devcel.2020.03.002

5.Maintenance of the adult Drosophila intestine: all roads lead to homeostasis.

Guo Z, Lucchetta E, Rafel N, Ohlstein B.

Curr Opin Genet Dev. 2016 Oct;40:81-86. doi: 10.1016/j.gde.2016.06.009. Epub 2016 Jul 5. Review.  PMID:27392294

https://doi.org/10.1016/j.gde.2016.06.009

4.Stem cell regulation. Bidirectional Notch signaling regulates Drosophila intestinal stem cell multipotency.

Guo Z, Ohlstein B.

Science. 2015 Nov 20;350(6263). pii: aab0988. doi: 10.1126/science.aab0988.  PMID:26586765

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3.Injury-induced BMP signaling negatively regulates Drosophila midgut homeostasis.

Guo Z, Driver I, Ohlstein B.

J Cell Biol. 2013 Jun 10;201(6):945-61. doi: 10.1083/jcb.201302049. Epub 2013 Jun 3.   PMID:23733344

https://doi.org/10.1083/jcb.201302049

2.The glypican Dally is required in the niche for the maintenance of germline stem cells and short-range BMP signaling in the Drosophila ovary.

Guo Z, Wang Z.

Development. 2009 Nov;136(21):3627-35. doi: 10.1242/dev.036939. Epub 2009 Sep 30.  PMID:19793889

https://doi.org/10.1242/dev.036939

1.TGFbeta receptor saxophone non-autonomously regulates germline proliferation in a Smox/dSmad2-dependent manner in Drosophila testis.

Li CY, Guo Z, Wang Z.

Dev Biol. 2007 Sep 1;309(1):70-7. doi: 10.1016/j.ydbio.2007.06.019. Epub 2007 Jul 3.  PMID:17651718

https://doi.org/10.1016/j.ydbio.2007.06.019

10.Apical-basal polarity precisely determines intestinal stem cell number by regulating Prospero threshold

Song Wu, Yang Yang, Ruizhi Tang, Song Zhang, Peizhong Qin, Rong Lin, Neus Rafel, Elena M. Lucchetta, Benjamin Ohlstein, Zheng Guo

Cell Reports. Volume 42, Issue 2, 2023, 112093, ISSN 2211-1247

https://doi.org/10.1016/j.celrep.2023.112093

11.Eclosion muscles secrete ecdysteroids to initiate asymmetric intestinal stem cell division in. 

Song Zhang, Song Wu, Ruining Yao, Xueying Wei, Benjamin Ohlstein, Zheng Guo

Developmental cell 59 (2024). DOI:10.1016/j.devcel.2023.11.016

https://doi.org/10.1016/j.devcel.2023.11.016

12.Dietary L-Glu sensing by enteroendocrine cells adjusts food intake via modulating gut PYY/NPF secretion. 

Junjun Gao, Song Zhang, Pan Deng, Zhigang Wu, Bruno Lemaitre, Zongzhao Zhai & Zheng Guo

Nature communications 15, 3514 (2024).

https://doi.org/10.1038/s41467-024-47465-4

13.Age mosaic of gut epithelial cells prevents aging. 

Peizhong Qin,Qi Wang, You Wu, Qiqi You, Mingyu Li & Zheng Guo

Nature communications 16, 6734 (2025).

https://doi.org/10.1038/s41467-025-62043-y

14.Reevaluation of whether histones are asymmetrically segregated during asymmetric divisions of stem cells in Drosophila.

Anqi Li, Dong Tong, Benjamin Ohlstein and Zheng Guo

Proceedings of the National Academy of Sciences of the United States of America 122, e2513015122 (2025). 

https://doi.org/10.1073/pnas.2513015122

15.Drosophila and mouse intestinal stem cells are spatiotemporally specified by Notch suppression and Wnt activation

You Wu, Lingxiao Yu, Yuxin Yu, Song Wu, Qili Yuan, Weicheng Duan, Sicheng Cai, Bo Xiong, Rong Lin and Zheng Guo

Science Advances.Volume 11,Issue 49,5 Dec 2025

https://doi.org/10.1126/sciadv.ady7272

16.Kuzbanian expression levels dictate Notch signaling outcomes via interplay between cis- and trans-Delta

Fenyu Shi,Li Qiao,You Wu and Zheng Guo

Development. 2026 Jan 15;153(2):dev204789.doi: 10.1242/dev.204789. Epub 2026 Jan 20. PMID: 41556123.

https://doi.org/10.1242/dev.204789

17.Intestinal stem cells count self-renewal divisions to switch multipotency

Tong Dong,Anqi Li,Quanquan Jiang,Qili Yuan,Xiaozhao Liu,Ximiao He,Jejunyi Liang,Yunyun Han,Zheng Guo

Nature, 656(8128), 742–751.

https://doi.org/10.1038/s41586-026-10814-y

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